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Endothelin‐1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species

BACKGROUND AND PURPOSE: Endothelin‐1 (ET‐1) is increased in patients with sickle cell disease and may contribute to the development of sickle cell nephropathy. The current study was designed to determine whether ET‐1 acting via the ET(A) receptor contributes to renal injury in a mouse model of sickl...

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Publicat a:Br J Pharmacol
Autors principals: Brett Heimlich, J, Speed, Joshua S, O'Connor, Paul M, Pollock, Jennifer S, Townes, Tim M, Meiler, Steffen E, Kutlar, Abdullah, Pollock, David M
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940621/
https://ncbi.nlm.nih.gov/pubmed/26561980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13380
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