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Near-atomic resolution visualization of human transcription promoter opening
In eukaryotic transcription initiation, a large multi-subunit pre-initiation complex (PIC) that assembles at the core promoter is required for the opening of the duplex DNA and identification of the start site for transcription by RNA polymerase II. Here we use cryo-electron microscropy (cryo-EM) to...
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| Veröffentlicht in: | Nature |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4940141/ https://ncbi.nlm.nih.gov/pubmed/27193682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17970 |
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