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Near-atomic resolution visualization of human transcription promoter opening

In eukaryotic transcription initiation, a large multi-subunit pre-initiation complex (PIC) that assembles at the core promoter is required for the opening of the duplex DNA and identification of the start site for transcription by RNA polymerase II. Here we use cryo-electron microscropy (cryo-EM) to...

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Bibliographische Detailangaben
Veröffentlicht in:Nature
Hauptverfasser: He, Yuan, Yan, Chunli, Fang, Jie, Inouye, Carla, Tjian, Robert, Ivanov, Ivaylo, Nogales, Eva
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940141/
https://ncbi.nlm.nih.gov/pubmed/27193682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17970
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