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Near-atomic resolution visualization of human transcription promoter opening

In eukaryotic transcription initiation, a large multi-subunit pre-initiation complex (PIC) that assembles at the core promoter is required for the opening of the duplex DNA and identification of the start site for transcription by RNA polymerase II. Here we use cryo-electron microscropy (cryo-EM) to...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: He, Yuan, Yan, Chunli, Fang, Jie, Inouye, Carla, Tjian, Robert, Ivanov, Ivaylo, Nogales, Eva
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940141/
https://ncbi.nlm.nih.gov/pubmed/27193682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17970
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