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Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation
Cellular senescence suppresses cancer by arresting cells at risk of malignant tumorigenesis. However, senescent cells also secrete molecules that can stimulate premalignant cells to proliferate and form tumors, suggesting the senescence response is antagonistically pleiotropic. We show that premalig...
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| Publicado no: | J Cell Sci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4939801/ https://ncbi.nlm.nih.gov/pubmed/15657080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.01635 |
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