A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen

Cellular senescence irreversibly arrests cell proliferation in response to oncogenic stimuli. Human cells develop a senescence-associated secretory phenotype (SASP), which increases the secretion of cytokines and other factors that alter the behavior of neighboring cells. We show here that “senescen...

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Detalhes bibliográficos
Main Authors: Coppé, Jean-Philippe, Patil, Christopher K., Rodier, Francis, Krtolica, Ana, Beauséjour, Christian M., Parrinello, Simona, Hodgson, J. Graeme, Chin, Koei, Desprez, Pierre-Yves, Campisi, Judith
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820538/
https://ncbi.nlm.nih.gov/pubmed/20169192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009188
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