Mechanism and Role of SOX2 Repression in Seminoma: Relevance to Human Germline Specification

Human male germ cell tumors (GCTs) are derived from primordial germ cells (PGCs). The master pluripotency regulator and neuroectodermal lineage effector transcription factor SOX2 is repressed in PGCs and the seminoma (SEM) subset of GCTs. The mechanism of SOX2 repression and its significance to GC a...

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Publicat a:Stem Cell Reports
Autors principals: Kushwaha, Ritu, Jagadish, Nirmala, Kustagi, Manjunath, Mendiratta, Geetu, Seandel, Marco, Soni, Rekha, Korkola, James E., Thodima, Venkata, Califano, Andrea, Bosl, George J., Chaganti, R.S.K.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939754/
https://ncbi.nlm.nih.gov/pubmed/27132888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.04.002
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