Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2–G2019S Mutation

Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) can cause Parkinson's disease (PD), and the most common disease-associated mutation, G2019S, increases kinase activity. Because LRRK2 expression levels rise during synaptogenesis and are highest in dorsal striatal spiny project...

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Pubblicato in:J Neurosci
Autori principali: Matikainen-Ankney, Bridget A., Kezunovic, Nebojsa, Mesias, Roxana E., Tian, Yuan, Williams, Frances M., Huntley, George W., Benson, Deanna L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2016
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938860/
https://ncbi.nlm.nih.gov/pubmed/27383589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3314-15.2016
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