G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice

Parkinson’s disease (PD) is a common neurodegenerative disease with a heterogeneous etiology that involves genetic and environmental factors or exogenous. Current LRRK2 PD animal models only partly reproduce the characteristics of the disease with very subtle dopaminergic neuron degeneration. We dev...

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Detalles Bibliográficos
Publicado en:Hum Mol Genet
Main Authors: Arbez, Nicolas, He, XiaoFei, Huang, Yong, Ren, Mark, Liang, Yideng, Nucifora, Frederick C, Wang, Xiaofang, Pei, Zhong, Tessarolo, Lino, Smith, Wanli W, Ross, Christopher A
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
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General Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068031/
https://ncbi.nlm.nih.gov/pubmed/31813996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz271
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