G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice

Parkinson’s disease (PD) is a common neurodegenerative disease with a heterogeneous etiology that involves genetic and environmental factors or exogenous. Current LRRK2 PD animal models only partly reproduce the characteristics of the disease with very subtle dopaminergic neuron degeneration. We dev...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Arbez, Nicolas, He, XiaoFei, Huang, Yong, Ren, Mark, Liang, Yideng, Nucifora, Frederick C, Wang, Xiaofang, Pei, Zhong, Tessarolo, Lino, Smith, Wanli W, Ross, Christopher A
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
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General Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068031/
https://ncbi.nlm.nih.gov/pubmed/31813996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz271
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