Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4

The Bromodomains and Extra-Terminal domain (BET) proteins direct gene transcription in chromatin, and represent new drug targets for cancer and inflammation. Here we report that the ET domain of the BET protein BRD4 recognizes an amphipathic protein sequence motif through establishing a two-strand a...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Structure
Päätekijät: Zhang, Qiang, Zeng, Lei, Shen, Chen, Ju, Ying, Konuma, Tsuyoshi, Zhao, Chengcheng, Vakoc, Christopher R., Zhou, Ming-Ming
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938737/
https://ncbi.nlm.nih.gov/pubmed/27291650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.04.019
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