Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4

The Bromodomains and Extra-Terminal domain (BET) proteins direct gene transcription in chromatin, and represent new drug targets for cancer and inflammation. Here we report that the ET domain of the BET protein BRD4 recognizes an amphipathic protein sequence motif through establishing a two-strand a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Structure
Hauptverfasser: Zhang, Qiang, Zeng, Lei, Shen, Chen, Ju, Ying, Konuma, Tsuyoshi, Zhao, Chengcheng, Vakoc, Christopher R., Zhou, Ming-Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938737/
https://ncbi.nlm.nih.gov/pubmed/27291650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.04.019
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