Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4

The Bromodomains and Extra-Terminal domain (BET) proteins direct gene transcription in chromatin, and represent new drug targets for cancer and inflammation. Here we report that the ET domain of the BET protein BRD4 recognizes an amphipathic protein sequence motif through establishing a two-strand a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Structure
Prif Awduron: Zhang, Qiang, Zeng, Lei, Shen, Chen, Ju, Ying, Konuma, Tsuyoshi, Zhao, Chengcheng, Vakoc, Christopher R., Zhou, Ming-Ming
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938737/
https://ncbi.nlm.nih.gov/pubmed/27291650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.04.019
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