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Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4
The Bromodomains and Extra-Terminal domain (BET) proteins direct gene transcription in chromatin, and represent new drug targets for cancer and inflammation. Here we report that the ET domain of the BET protein BRD4 recognizes an amphipathic protein sequence motif through establishing a two-strand a...
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| Publicado no: | Structure |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4938737/ https://ncbi.nlm.nih.gov/pubmed/27291650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.04.019 |
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