Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4

Jumonji domain-containing protein 6 (JMJD6) is a member of the Jumonji C family of Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases. It possesses unique bi-functional oxygenase activities, acting as both an arginine demethylase and a lysyl-hydroxylase. JMJD6 has been reported to be over-expresse...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Konuma, Tsuyoshi, Yu, Di, Zhao, Chengcheng, Ju, Ying, Sharma, Rajal, Ren, Chunyan, Zhang, Qiang, Zhou, Ming-Ming, Zeng, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701133/
https://ncbi.nlm.nih.gov/pubmed/29176719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16588-8
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