Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation

The BET proteins are major transcriptional regulators and have emerged as new drug targets, but their functional distinction has remained elusive. In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic functions at genes whose transcription they co-regulate during...

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Udgivet i:Mol Cell
Main Authors: Cheung, Ka Lung, Zhang, Fan, Jaganathan, Anbalagan, Sharma, Rajal, Zhang, Qiang, Konuma, Tsuyoshi, Shen, Tong, Lee, June-Yong, Ren, Chunyan, Chen, Chih-Hung, Lu, Geming, Olson, Matthew R., Zhang, Weijia, Kaplan, Mark H., Littman, Dan R., Walsh, Martin J., Xiong, Huabao, Zeng, Lei, Zhou, Ming-Ming
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357147/
https://ncbi.nlm.nih.gov/pubmed/28262505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.12.022
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