NSD3-short is an adaptor protein that couples BRD4 to the CHD8 chromatin remodeler

The bromodomain and extraterminal (BET) protein BRD4 is a therapeutic target in acute myeloid leukemia (AML). Here, we demonstrate that the AML maintenance function of BRD4 requires its interaction with NSD3, which belongs to a subfamily of H3K36 methyltransferases. Unexpectedly, AML cells were foun...

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Udgivet i:Mol Cell
Main Authors: Shen, Chen, Ipsaro, Jonathan J., Shi, Junwei, Milazzo, Joseph A., Wang, Eric, Roe, Jae-Seok, Suzuki, Yutaka, Pappin, Darryl J., Joshua-Tor, Leemor, Vakoc, Christopher R.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688131/
https://ncbi.nlm.nih.gov/pubmed/26626481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.10.033
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