Proinsulin Shares a Motif with Interleukin-1α (IL-1α) and Induces Inflammatory Cytokine via Interleukin-1 Receptor 1

Although it has been established that diabetes increases susceptibility to infections, the role of insulin (INS) in the immune response is unknown. Here, we investigated the immunological function of INS. Proinsulin dimer (pINSd) was a potent immune stimulus that induced inflammatory cytokines, but...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Lee, Siyoung, Kim, Eunsom, Jhun, Hyunjhung, Hong, Jaewoo, Kwak, Areum, Jo, Seunghyun, Bae, Suyoung, Lee, Jongho, Kim, Busun, Lee, Jungmin, Youn, Sulah, Kim, Somi, Kim, Miyeon, Kim, Hyunwoo, Lee, Youngmin, Choi, Dong-Ki, Kim, Yong-Sung, Kim, Soohyun
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938183/
https://ncbi.nlm.nih.gov/pubmed/27226621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.731026
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