Proinsulin Shares a Motif with Interleukin-1α (IL-1α) and Induces Inflammatory Cytokine via Interleukin-1 Receptor 1

Although it has been established that diabetes increases susceptibility to infections, the role of insulin (INS) in the immune response is unknown. Here, we investigated the immunological function of INS. Proinsulin dimer (pINSd) was a potent immune stimulus that induced inflammatory cytokines, but...

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Vydáno v:J Biol Chem
Hlavní autoři: Lee, Siyoung, Kim, Eunsom, Jhun, Hyunjhung, Hong, Jaewoo, Kwak, Areum, Jo, Seunghyun, Bae, Suyoung, Lee, Jongho, Kim, Busun, Lee, Jungmin, Youn, Sulah, Kim, Somi, Kim, Miyeon, Kim, Hyunwoo, Lee, Youngmin, Choi, Dong-Ki, Kim, Yong-Sung, Kim, Soohyun
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938183/
https://ncbi.nlm.nih.gov/pubmed/27226621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.731026
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