Proinsulin Shares a Motif with Interleukin-1α (IL-1α) and Induces Inflammatory Cytokine via Interleukin-1 Receptor 1

Although it has been established that diabetes increases susceptibility to infections, the role of insulin (INS) in the immune response is unknown. Here, we investigated the immunological function of INS. Proinsulin dimer (pINSd) was a potent immune stimulus that induced inflammatory cytokines, but...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Lee, Siyoung, Kim, Eunsom, Jhun, Hyunjhung, Hong, Jaewoo, Kwak, Areum, Jo, Seunghyun, Bae, Suyoung, Lee, Jongho, Kim, Busun, Lee, Jungmin, Youn, Sulah, Kim, Somi, Kim, Miyeon, Kim, Hyunwoo, Lee, Youngmin, Choi, Dong-Ki, Kim, Yong-Sung, Kim, Soohyun
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938183/
https://ncbi.nlm.nih.gov/pubmed/27226621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.731026
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