Visualizing Antibody Affinity Maturation in Germinal Centers

Antibodies somatically mutate to attain high affinity in germinal centers (GCs). There, competition between B cell clones and among somatic mutants of each clone drives an increase in average affinity across the population. The extent to which higher-affinity cells eliminating competitors restricts...

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Veröffentlicht in:Science
Hauptverfasser: Tas, Jeroen M.J., Mesin, Luka, Pasqual, Giulia, Targ, Sasha, Jacobsen, Johanne T., Mano, Yasuko M., Chen, Casie S., Weill, Jean-Claude, Reynaud, Claude-Agnès, Browne, Edward P., Meyer-Hermann, Michael, Victora, Gabriel D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938154/
https://ncbi.nlm.nih.gov/pubmed/26912368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad3439
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