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Visualizing Antibody Affinity Maturation in Germinal Centers
Antibodies somatically mutate to attain high affinity in germinal centers (GCs). There, competition between B cell clones and among somatic mutants of each clone drives an increase in average affinity across the population. The extent to which higher-affinity cells eliminating competitors restricts...
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| Publicado en: | Science |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4938154/ https://ncbi.nlm.nih.gov/pubmed/26912368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad3439 |
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