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Clonal Evolution of Autoreactive Germinal Centers
Germinal centers (GCs) are the primary sites of clonal B cell expansion and affinity maturation, directing the production of high-affinity antibodies. This response is a central driver of pathogenesis in autoimmune diseases, such as systemic lupus erythematosus (SLE), but the natural history of auto...
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Publicado no: | Cell |
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Main Authors: | , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5784431/ https://ncbi.nlm.nih.gov/pubmed/28841417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.07.026 |
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