Clonal Evolution of Autoreactive Germinal Centers

Germinal centers (GCs) are the primary sites of clonal B cell expansion and affinity maturation, directing the production of high-affinity antibodies. This response is a central driver of pathogenesis in autoimmune diseases, such as systemic lupus erythematosus (SLE), but the natural history of auto...

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Publicat a:Cell
Autors principals: Degn, Søren E., van der Poel, Cees E., Firl, Daniel J., Ayoglu, Burcu, Al Qureshah, Fahd A., Bajic, Goran, Mesin, Luka, Reynaud, Claude-Agnès, Weill, Jean-Claude, Utz, Paul J., Victora, Gabriel D., Carroll, Michael C.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784431/
https://ncbi.nlm.nih.gov/pubmed/28841417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.07.026
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