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Identification of metabolites of dalfampridine (4-aminopyridine) in dog and rat

BACKGROUND: Dalfampridine (4-aminopyridine; 4-AP) is a potassium channel blocker available in the United States to improve walking in patients with multiple sclerosis as demonstrated by an increase in walking speed. Its pharmacokinetics have been evaluated in human studies but its metabolites are no...

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Bibliografske podrobnosti
izdano v:J Drug Assess
Main Authors: Caggiano, Anthony, Blight, Andrew, Parry, Tom J.
Format: Artigo
Jezik:Inglês
Izdano: Maney Publishing 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937651/
https://ncbi.nlm.nih.gov/pubmed/27536440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/21556660.2013.794143
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