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Effects of dalfampridine and its metabolites on cloned human potassium channels K(v) 1.1, K(v) 1.2, and K(v) 1.4 expressed in human embryonic kidney cells

BACKGROUND: Dalfampridine (4-aminopyridine; 4-AP) is a potassium channel blocker that has been available in the United States as a treatment to improve walking in patients with multiple sclerosis. 4-AP is well-characterized in vitro with regard to inhibition of neuronal potassium channels, but the p...

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Detalhes bibliográficos
Publicado no:J Drug Assess
Main Authors: Caggiano, Anthony, Blight, Andrew, Parry, Tom J.
Formato: Artigo
Idioma:Inglês
Publicado em: Maney Publishing 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937658/
https://ncbi.nlm.nih.gov/pubmed/27536438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/21556660.2013.791623
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