Identification of metabolites of dalfampridine (4-aminopyridine) in dog and rat

BACKGROUND: Dalfampridine (4-aminopyridine; 4-AP) is a potassium channel blocker available in the United States to improve walking in patients with multiple sclerosis as demonstrated by an increase in walking speed. Its pharmacokinetics have been evaluated in human studies but its metabolites are no...

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Bibliographic Details
Published in:J Drug Assess
Main Authors: Caggiano, Anthony, Blight, Andrew, Parry, Tom J.
Format: Artigo
Language:Inglês
Published: Maney Publishing 2013
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937651/
https://ncbi.nlm.nih.gov/pubmed/27536440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/21556660.2013.794143
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