Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells

Ultraviolet-induced 6-4 photoproducts (6-4PP) and cyclobutane pyrimidine dimers (CPD) can be tolerated by translesion DNA polymerases (TLS Pols) at stalled replication forks or by gap-filling. Here, we investigated the involvement of Polη, Rev1 and Rev3L (Polζ catalytic subunit) in the specific bypa...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Quinet, Annabel, Martins, Davi Jardim, Vessoni, Alexandre Teixeira, Biard, Denis, Sarasin, Alain, Stary, Anne, Menck, Carlos Frederico Martins
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937316/
https://ncbi.nlm.nih.gov/pubmed/27095204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw280
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