Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells

Genome lesions trigger biological responses that help cells manage damaged DNA, improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses lesions that block replicative polymerases, avoiding continued stalling of replication forks, which could lead to cell death. p53...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Lerner, Leticia K., Francisco, Guilherme, Soltys, Daniela T., Rocha, Clarissa R.R., Quinet, Annabel, Vessoni, Alexandre T., Castro, Ligia P., David, Taynah I.P., Bustos, Silvina O., Strauss, Bryan E., Gottifredi, Vanesa, Stary, Anne, Sarasin, Alain, Chammas, Roger, Menck, Carlos F.M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388406/
https://ncbi.nlm.nih.gov/pubmed/28180309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1196
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