Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells

Genome lesions trigger biological responses that help cells manage damaged DNA, improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses lesions that block replicative polymerases, avoiding continued stalling of replication forks, which could lead to cell death. p53...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Lerner, Leticia K., Francisco, Guilherme, Soltys, Daniela T., Rocha, Clarissa R.R., Quinet, Annabel, Vessoni, Alexandre T., Castro, Ligia P., David, Taynah I.P., Bustos, Silvina O., Strauss, Bryan E., Gottifredi, Vanesa, Stary, Anne, Sarasin, Alain, Chammas, Roger, Menck, Carlos F.M.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388406/
https://ncbi.nlm.nih.gov/pubmed/28180309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1196
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