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Pirh2 E3 Ubiquitin Ligase Monoubiquitinates DNA Polymerase Eta To Suppress Translesion DNA Synthesis

Polymerase eta (PolH) is necessary for translesion DNA synthesis, and PolH deficiency predisposes xeroderma pigmentosum variant (XPV) patients to cancer. Due to the critical role of PolH in translesion DNA synthesis, the activity of PolH is tightly controlled and subjected to multiple regulations, e...

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Bibliografski detalji
Glavni autori: Jung, Yong-Sam, Hakem, Anne, Hakem, Razqallah, Chen, Xinbin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187371/
https://ncbi.nlm.nih.gov/pubmed/21791603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05808-11
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