Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts

In eukaryotic cells, the Rad6/Rad18-dependent monoubiquitination of the proliferating cell nuclear antigen (PCNA) plays an essential role in the switching between replication and translesion DNA synthesis (TLS). The DNA polymerase Polη binds to PCNA via a consensus C-terminal PCNA-interacting protei...

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Detalhes bibliográficos
Main Authors: Schmutz, Valérie, Janel-Bintz, Régine, Wagner, Jérôme, Biard, Denis, Shiomi, Naoko, Fuchs, Robert P., Cordonnier, Agnès M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965212/
https://ncbi.nlm.nih.gov/pubmed/20529881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq403
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