Evidence for a Rad18-Independent Frameshift Mutagenesis Pathway in Human Cell-Free Extracts

Bypass of replication blocks by specialized DNA polymerases is crucial for cell survival but may promote mutagenesis and genome instability. To gain insight into mutagenic sub-pathways that coexist in mammalian cells, we examined N-2-acetylaminofluorene (AAF)-induced frameshift mutagenesis by means...

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Detalhes bibliográficos
Main Authors: Janel-Bintz, Régine, Wagner, Jérôme, Haracska, Lajos, Mah-Becherel, Marcia Chia Miao, Bichara, Marc, Fuchs, Robert P., Cordonnier, Agnès M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338768/
https://ncbi.nlm.nih.gov/pubmed/22558303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036004
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