Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids

TRIM5 proteins are restriction factors that block retroviral infections by binding viral capsids and preventing reverse transcription. Capsid recognition is mediated by C-terminal domains on TRIM5α (SPRY) or TRIMCyp (cyclophilin A), which interact weakly with capsids. Efficient capsid recognition al...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Li, Yen-Li, Chandrasekaran, Viswanathan, Carter, Stephen D, Woodward, Cora L, Christensen, Devin E, Dryden, Kelly A, Pornillos, Owen, Yeager, Mark, Ganser-Pornillos, Barbie K, Jensen, Grant J, Sundquist, Wesley I
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936896/
https://ncbi.nlm.nih.gov/pubmed/27253068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16269
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