Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro

During the first half of the viral life cycle, HIV-1 reverse transcribes its RNA genome and integrates the double-stranded DNA copy into a host cell chromosome. Despite progress in characterizing and inhibiting these processes, in situ mechanistic and structural studies remain challenging. This is b...

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Bibliographic Details
Published in:Science
Main Authors: Christensen, Devin E., Ganser-Pornillos, Barbie K., Johnson, Jarrod S., Pornillos, Owen, Sundquist, Wesley I.
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8022914/
https://ncbi.nlm.nih.gov/pubmed/33033190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abc8420
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