Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation

Amyloid precursor protein (APP) and its cleavage product amyloid β (Aβ) have been thoroughly studied in Alzheimer’s disease. However, APP also appears to be important for neuronal development. Differentiation of induced pluripotent stem cells (iPSCs) towards cortical neurons enables in vitro mechani...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Bergström, Petra, Agholme, Lotta, Nazir, Faisal Hayat, Satir, Tugce Munise, Toombs, Jamie, Wellington, Henrietta, Strandberg, Joakim, Bontell, Thomas Olsson, Kvartsberg, Hlin, Holmström, Maria, Boreström, Cecilia, Simonsson, Stina, Kunath, Tilo, Lindahl, Anders, Blennow, Kaj, Hanse, Eric, Portelius, Erik, Wray, Selina, Zetterberg, Henrik
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935877/
https://ncbi.nlm.nih.gov/pubmed/27383650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29200
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