Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation

Amyloid precursor protein (APP) and its cleavage product amyloid β (Aβ) have been thoroughly studied in Alzheimer’s disease. However, APP also appears to be important for neuronal development. Differentiation of induced pluripotent stem cells (iPSCs) towards cortical neurons enables in vitro mechani...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bergström, Petra, Agholme, Lotta, Nazir, Faisal Hayat, Satir, Tugce Munise, Toombs, Jamie, Wellington, Henrietta, Strandberg, Joakim, Bontell, Thomas Olsson, Kvartsberg, Hlin, Holmström, Maria, Boreström, Cecilia, Simonsson, Stina, Kunath, Tilo, Lindahl, Anders, Blennow, Kaj, Hanse, Eric, Portelius, Erik, Wray, Selina, Zetterberg, Henrik
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935877/
https://ncbi.nlm.nih.gov/pubmed/27383650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29200
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