Lysines in the tetramerization domain of p53 selectively modulate G1 arrest

Functional in a tetrameric state, the protein product of the p53 tumor suppressor gene confers its tumor-suppressive activity by transactivating genes which promote cell-cycle arrest, senescence, or programmed cell death. How p53 distinguishes between these divergent outcomes is still a matter of co...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Cycle
Hauptverfasser: Beckerman, Rachel, Yoh, Kathryn, Mattia-Sansobrino, Melissa, Zupnick, Andrew, Laptenko, Oleg, Karni-Schmidt, Orit, Ahn, Jinwoo, Byeon, In-Ja, Keezer, Susan, Prives, Carol
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2016
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934057/
https://ncbi.nlm.nih.gov/pubmed/27210019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1170270
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