A Replication-Defective Human Type 5 Adenovirus-Based Trivalent Vaccine Confers Complete Protection against Plague in Mice and Nonhuman Primates

Currently, no plague vaccine exists in the United States for human use. The capsular antigen (Caf1 or F1) and two type 3 secretion system (T3SS) components, the low-calcium-response V antigen (LcrV) and the needle protein YscF, represent protective antigens of Yersinia pestis. We used a replication-...

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Dades bibliogràfiques
Publicat a:Clin Vaccine Immunol
Autors principals: Sha, Jian, Kirtley, Michelle L., Klages, Curtis, Erova, Tatiana E., Telepnev, Maxim, Ponnusamy, Duraisamy, Fitts, Eric C., Baze, Wallace B., Sivasubramani, Satheesh K., Lawrence, William S., Patrikeev, Igor, Peel, Jennifer E., Andersson, Jourdan A., Kozlova, Elena V., Tiner, Bethany L., Peterson, Johnny W., McWilliams, David, Patel, Snehal, Rothe, Eric, Motin, Vladimir L., Chopra, Ashok K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Vaccines
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933772/
https://ncbi.nlm.nih.gov/pubmed/27170642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00150-16
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