A Replication-Defective Human Type 5 Adenovirus-Based Trivalent Vaccine Confers Complete Protection against Plague in Mice and Nonhuman Primates

Currently, no plague vaccine exists in the United States for human use. The capsular antigen (Caf1 or F1) and two type 3 secretion system (T3SS) components, the low-calcium-response V antigen (LcrV) and the needle protein YscF, represent protective antigens of Yersinia pestis. We used a replication-...

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Bibliografiske detaljer
Udgivet i:Clin Vaccine Immunol
Main Authors: Sha, Jian, Kirtley, Michelle L., Klages, Curtis, Erova, Tatiana E., Telepnev, Maxim, Ponnusamy, Duraisamy, Fitts, Eric C., Baze, Wallace B., Sivasubramani, Satheesh K., Lawrence, William S., Patrikeev, Igor, Peel, Jennifer E., Andersson, Jourdan A., Kozlova, Elena V., Tiner, Bethany L., Peterson, Johnny W., McWilliams, David, Patel, Snehal, Rothe, Eric, Motin, Vladimir L., Chopra, Ashok K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Vaccines
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933772/
https://ncbi.nlm.nih.gov/pubmed/27170642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00150-16
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