A Replication-Defective Human Type 5 Adenovirus-Based Trivalent Vaccine Confers Complete Protection against Plague in Mice and Nonhuman Primates

Currently, no plague vaccine exists in the United States for human use. The capsular antigen (Caf1 or F1) and two type 3 secretion system (T3SS) components, the low-calcium-response V antigen (LcrV) and the needle protein YscF, represent protective antigens of Yersinia pestis. We used a replication-...

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Detalles Bibliográficos
Publicado en:Clin Vaccine Immunol
Autores principales: Sha, Jian, Kirtley, Michelle L., Klages, Curtis, Erova, Tatiana E., Telepnev, Maxim, Ponnusamy, Duraisamy, Fitts, Eric C., Baze, Wallace B., Sivasubramani, Satheesh K., Lawrence, William S., Patrikeev, Igor, Peel, Jennifer E., Andersson, Jourdan A., Kozlova, Elena V., Tiner, Bethany L., Peterson, Johnny W., McWilliams, David, Patel, Snehal, Rothe, Eric, Motin, Vladimir L., Chopra, Ashok K.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
Materias:
Vaccines
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933772/
https://ncbi.nlm.nih.gov/pubmed/27170642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00150-16
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