Combinational Deletion of Three Membrane Protein-Encoding Genes Highly Attenuates Yersinia pestis while Retaining Immunogenicity in a Mouse Model of Pneumonic Plague

Previously, we showed that deletion of genes encoding Braun lipoprotein (Lpp) and MsbB attenuated Yersinia pestis CO92 in mouse and rat models of bubonic and pneumonic plague. While Lpp activates Toll-like receptor 2, the MsbB acyltransferase modifies lipopolysaccharide. Here, we deleted the ail gen...

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Udgivet i:Infect Immun
Main Authors: Tiner, Bethany L., Sha, Jian, Kirtley, Michelle L., Erova, Tatiana E., Popov, Vsevolod L., Baze, Wallace B., van Lier, Christina J., Ponnusamy, Duraisamy, Andersson, Jourdan A., Motin, Vladimir L., Chauhan, Sadhana, Chopra, Ashok K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Molecular Pathogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363438/
https://ncbi.nlm.nih.gov/pubmed/25605764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02778-14
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