Combinational Deletion of Three Membrane Protein-Encoding Genes Highly Attenuates Yersinia pestis while Retaining Immunogenicity in a Mouse Model of Pneumonic Plague

Previously, we showed that deletion of genes encoding Braun lipoprotein (Lpp) and MsbB attenuated Yersinia pestis CO92 in mouse and rat models of bubonic and pneumonic plague. While Lpp activates Toll-like receptor 2, the MsbB acyltransferase modifies lipopolysaccharide. Here, we deleted the ail gen...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Infect Immun
Prif Awduron: Tiner, Bethany L., Sha, Jian, Kirtley, Michelle L., Erova, Tatiana E., Popov, Vsevolod L., Baze, Wallace B., van Lier, Christina J., Ponnusamy, Duraisamy, Andersson, Jourdan A., Motin, Vladimir L., Chauhan, Sadhana, Chopra, Ashok K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2015
Pynciau:
Molecular Pathogenesis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363438/
https://ncbi.nlm.nih.gov/pubmed/25605764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02778-14
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