Deletion of Braun Lipoprotein and Plasminogen-Activating Protease-Encoding Genes Attenuates Yersinia pestis in Mouse Models of Bubonic and Pneumonic Plague

Currently, there is no FDA-approved vaccine against Yersinia pestis, the causative agent of bubonic and pneumonic plague. Since both humoral immunity and cell-mediated immunity are essential in providing the host with protection against plague, we developed a live-attenuated vaccine strain by deleti...

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Autori principali: van Lier, Christina J., Sha, Jian, Kirtley, Michelle L., Cao, Anthony, Tiner, Bethany L., Erova, Tatiana E., Cong, Yingzi, Kozlova, Elena V., Popov, Vsevolod L., Baze, Wallace B., Chopra, Ashok K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Molecular Pathogenesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019162/
https://ncbi.nlm.nih.gov/pubmed/24686064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01595-13
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