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Edelfosine Promotes Apoptosis in Androgen Deprived Prostate Tumors by Increasing ATF3 and Inhibiting Androgen Receptor Activity

Edelfosine is a synthetic alkyl-lysophospholipid (ALP) that possesses significant antitumor activity in several human tumor models. Here, we investigated the effects of edelfosine combined with androgen deprivation (AD) in LNCaP and VCaP human prostate cancer cells. This treatment regimen greatly de...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Udayakumar, Thirupandiyur S., Stoyanova, Radka, Shareef, Mohammed M., Mu, Zhaomei, Philip, Sakhi, Burnstein, Kerry L., Pollack, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933508/
https://ncbi.nlm.nih.gov/pubmed/26944919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0332
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