Antisense MDM2 Enhances the Response of Androgen Insensitive Human Prostate Cancer Cells to Androgen Deprivation In Vitro and In Vivo

BACKGROUND: Antisense MDM2 oligonucleotide (AS-MDM2) sensitizes androgen sensitive LNCaP cells to androgen deprivation (AD) in vitro and in vivo. In this study, we investigated the effects of AS-MDM2 combined with AD on androgen resistant LNCaP (LNCaP-Res) and moderately androgen resistant bcl-2 ove...

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Hauptverfasser: Mu, Zhaomei, Hachem, Paul, Hensley, Harvey, Stoyanova, Radka, Kwon, Hae Won, Hanlon, Alexandra L., Agrawal, Sudhir, Pollack, Alan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763092/
https://ncbi.nlm.nih.gov/pubmed/18196567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.20731
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