ANTISENSE-MDM2 SENSITIZES LNCaP PROSTATE CANCER CELLS TO ANDROGEN DEPRIVATION, RADIATION, AND THE COMBINATION IN VIVO

PURPOSE: To test the effects of antisense (AS)-MDM2 alone and with androgen deprivation (AD), radiotherapy (RT), and AD + RT on wild-type LNCaP cells in an orthotopic in vivo model. METHODS: Androgen-sensitive LNCaP cells were grown in the prostates of nude mice. Magnetic resonance imaging–based tum...

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Detalhes bibliográficos
Main Authors: Stoyanova, Radka, Hachem, Paul, Hensley, Harvey, Khor, Li-Yan, Mu, Zhaomei, Hammond, M. Elizabeth H., Agrawal, Sudhir, Pollack, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763094/
https://ncbi.nlm.nih.gov/pubmed/17637390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2007.03.047
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