Receptor for Activated C Kinase 1 (RACK1) Promotes Dishevelled Protein Degradation via Autophagy and Antagonizes Wnt Signaling

Wnt signaling plays a critical role in embryonic development, tissue homeostasis, and cancer development. Dishevelled (Dvl) is an essential and central component in Wnt signaling, and its stability and activity is tightly regulated. It has been shown that Dvl can be degraded via both the proteasome...

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Foilsithe in:J Biol Chem
Main Authors: Cheng, Minzhang, Xue, Hua, Cao, Weipeng, Li, Wenxia, Chen, Hua, Liu, Bofeng, Ma, Benyu, Yan, Xiaohua, Chen, Ye-Guang
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2016
Ábhair:
Signal Transduction
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933469/
https://ncbi.nlm.nih.gov/pubmed/27129200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.708818
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