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The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy

Autophagy is a regulated process that sequesters and transports cytoplasmic materials such as protein aggregates via autophagosomes to lysosomes for degradation. Dapper1 (Dpr1), an interacting protein of Dishevelled (Dvl), antagonizes Wnt signaling by promoting Dishevelled degradation via lysosomes....

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ma, Benyu, Liu, Bofeng, Cao, Weipeng, Gao, Chan, Qi, Zhen, Ning, Yuanheng, Chen, Ye-Guang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424364/
https://ncbi.nlm.nih.gov/pubmed/25825496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.654590
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