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The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy

Autophagy is a regulated process that sequesters and transports cytoplasmic materials such as protein aggregates via autophagosomes to lysosomes for degradation. Dapper1 (Dpr1), an interacting protein of Dishevelled (Dvl), antagonizes Wnt signaling by promoting Dishevelled degradation via lysosomes....

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Vydáno v:J Biol Chem
Hlavní autoři: Ma, Benyu, Liu, Bofeng, Cao, Weipeng, Gao, Chan, Qi, Zhen, Ning, Yuanheng, Chen, Ye-Guang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424364/
https://ncbi.nlm.nih.gov/pubmed/25825496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.654590
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