Protein Kinase A-mediated 14-3-3 Association Impedes Human Dapper1 to Promote Dishevelled Degradation

Wnt signaling regulates embryo development and tissue homeostasis, and its deregulation leads to an array of diseases, including cancer. Dapper1 has been shown to be a key negative regulator of Wnt signaling. However, its function and regulation remain poorly understood. In this study, we report tha...

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Bibliografiska uppgifter
Huvudupphovsmän: Chen, Hua, Liu, Linhua, Ma, Benyu, Ma, Ting Martin, Hou, Jun-Jie, Xie, Guo-Ming, Wu, Wei, Yang, Fu-Quan, Chen, Ye-Guang
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083226/
https://ncbi.nlm.nih.gov/pubmed/21262972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.211607
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