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Myristoylated Naked2 Antagonizes Wnt-β-Catenin Activity by Degrading Dishevelled-1 at the Plasma Membrane

In Drosophila, naked cuticle is an inducible antagonist of the Wnt-β-catenin pathway, likely acting at the level of Dishevelled (Dsh/Dvl), an essential component of this pathway. The mechanism by which naked cuticle and its two vertebrate orthologs, Naked1 (NKD1) and Naked2 (NKD2), inhibit Dvl funct...

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Detalhes bibliográficos
Main Authors: Hu, Tianhui, Li, Cunxi, Cao, Zheng, Van Raay, Terence J., Smith, Jason G., Willert, Karl, Solnica-Krezel, Lila, Coffey, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859517/
https://ncbi.nlm.nih.gov/pubmed/20177058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.075945
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