Naked1 Antagonizes Wnt Signaling by Preventing Nuclear Accumulation of β-Catenin

Cyto-nuclear shuttling of β-catenin is at the epicenter of the canonical Wnt pathway and mutations in genes that result in excessive nuclear accumulation of β-catenin are the driving force behind the initiation of many cancers. Recently, Naked Cuticle homolog 1 (Nkd1) has been identified as a Wnt-in...

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Autors principals: Van Raay, Terence J., Fortino, Nicholas J., Miller, Bryan W., Ma, Haiting, Lau, Garnet, Li, Cunxi, Franklin, Jeffery L., Attisano, Liliana, Solnica-Krezel, Lilianna, Coffey, Robert J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072412/
https://ncbi.nlm.nih.gov/pubmed/21490931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018650
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