Direct Demonstration That Loop1 of Scap Binds to Loop7: A CRUCIAL EVENT IN CHOLESTEROL HOMEOSTASIS

Cholesterol homeostasis is mediated by Scap, a polytopic endoplasmic reticulum (ER) protein that transports sterol regulatory element-binding proteins from the ER to Golgi, where they are processed to forms that activate cholesterol synthesis. Scap has eight transmembrane helices and two large lumin...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhang, Yinxin, Lee, Kwang Min, Kinch, Lisa N., Clark, Lindsay, Grishin, Nick V., Rosenbaum, Daniel M., Brown, Michael S., Goldstein, Joseph L., Radhakrishnan, Arun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933461/
https://ncbi.nlm.nih.gov/pubmed/27068746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.729798
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