Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism

In mammals, pyruvate kinase (PK) plays a key role in regulating the balance between glycolysis and gluconeogenesis; however, in vivo regulation of PK flux by gluconeogenic hormones and substrates is poorly understood. To this end, we developed a novel NMR-liquid chromatography/tandem-mass spectromet...

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Vydáno v:J Biol Chem
Hlavní autoři: Perry, Rachel J., Borders, Candace B., Cline, Gary W., Zhang, Xian-Man, Alves, Tiago C., Petersen, Kitt Falk, Rothman, Douglas L., Kibbey, Richard G., Shulman, Gerald I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933266/
https://ncbi.nlm.nih.gov/pubmed/27002151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.720631
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