Phosphoenolpyruvate Cycling via Mitochondrial Phosphoenolpyruvate Carboxykinase Links Anaplerosis and Mitochondrial GTP with Insulin Secretion

Pancreatic β-cells couple the oxidation of glucose to the secretion of insulin. Apart from the canonical K(ATP)-dependent glucose-stimulated insulin secretion (GSIS), there are important K(ATP)-independent mechanisms involving both anaplerosis and mitochondrial GTP (mtGTP). How mtGTP that is trapped...

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Autori principali: Stark, Romana, Pasquel, Francisco, Turcu, Adina, Pongratz, Rebecca L., Roden, Michael, Cline, Gary W., Shulman, Gerald I., Kibbey, Richard G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Metabolism and Bioenergetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785346/
https://ncbi.nlm.nih.gov/pubmed/19635791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.011775
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